Summary
An excess of heterozygotes over Hardy-Weinberg expectations at a protein locus has been observed in both natural and experimental populations of Drosophila paulistorum. Data are presented which rule out the possibility of the excess being caused by association of alleles with heterotic karyotypes. A spurious excess of heterozygotes owing to directional selection is also ruled out. Arguments are put forth which makes associative overdominance unlikely. It is likely that heterosis is acting at this locus to maintain the polymorphism.
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Powell, J. Heterosis at an enzyme locus of drosophila: evidence from experimental populations. Heredity 32, 105–108 (1974). https://doi.org/10.1038/hdy.1974.9
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DOI: https://doi.org/10.1038/hdy.1974.9
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