Summary
Some current estimators of the relative viabilities of genotypes used in competition experiments, are shown to be biased, the bias being a function of the sample size and the gene frequency. From their use, an erroneous conclusion of a frequency-dependent phenomenon can be drawn. Almost unbiased estimators are advocated. The calculation of the exact distribution of these estimators for each experimental situation is the only correct way to test the significance of an observed value.
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Anxolabehere, D., Goux, J. & Periquet, G. A bias in estimation of viabilities from competition experiments. Heredity 48, 271–282 (1982). https://doi.org/10.1038/hdy.1982.32
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DOI: https://doi.org/10.1038/hdy.1982.32
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