Abstract
The genetic architectures of 12 behavioural variables measured in adult male mice placed in a novel environment were analysed in a replicated 4×4 diallel cross. The results were combined with those obtained in a classical cross involving two of the four strains. Based on the hypothesis of an evolutionary history of stabilising selection for mouse exploratory behaviour, we expected additive genetic effects and ambidirectional dominance. Such genetic architectures were actually found for those exploratory behaviours where epistatic effects were of minor importance. Similar findings emerged for some non-exploratory phenotypes. All behaviours analysed appeared to be polygenically controlled.
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References
Barnett, S A. 1958. Exploratory behaviour. Br J Psychol, 49, 289–310.
Barnett, S A, and Cowan, P E. 1976. Activity, exploration, curiosity and fear: An ethological study. Interdisc Sci Rev, 1, 43–62.
Broadhurst, P L. 1960. Applications of biometrical genetics to the inheritance of behaviour. In H. J. Eysenck (ed.), Experiments in Personality Vol I Psychogenetics and Psychopharmacology. London, Routledge and Kegan Paul.
Broadhurst, P L, and Jinks, J L. 1974. What genetical architecture can tell us about the natural selection of behavioural traits. In J. H. F. van Abeelen (ed.), The Genetics of Behaviour, Amsterdam, North-Holland and New York, American Elsevier.
Cavalli, L L. 1952. An analysis of linkage in quantitative inheritance. In E. C. R. Reeve and C. H. Waddington (eds.), Quantitative Inheritance, London, HMSO.
Crusio, W E, Kerbusch, J M L, and Van Abeelen, J H F. 1984. The replicated diallel cross: A generalized method of analysis. Behav Genet, 14, 81–104.
Fisher, R A. 1958. The Genetical Theory of Natural Selection, New York, Dover Publications.
Gale, J G, Mather, K, and Jinks, J L. 1977. Joint scaling tests. Heredity, 38, 47–51.
Godoy-Herrera, R, Burnet, B, Connolly, K, and Gogarty, J. 1984. The development of locomotor activity in Drosophila melanogaster larvae. Heredity, 52, 63–75.
Hayman, B I. 1954a. The analysis of variance of diallel tables. Biometrics, 10, 235–244.
Hayman, B I. 1954b. The theory and analysis of diallel crosses. Genetics, 39, 789–809.
Kerbusch, J M L, and Van Abeelen, J H F. 1981. Behavioral responses to novelty in mice: A reanalysis. Behav Genet, 11, 373–377.
Kerbusch, J M L, Van Der Staay, F J, and Hendriks, N. 1981. A searching procedure for transformations and models in a classical mendelian cross breeding study. Behav Genet, 11, 239–254.
Lush, I E. 1981. Mouse pharmacogenetics. In R. J. Berry (ed.) Biology of the House Mouse, London, Academic Press.
Mather, K. 1973. Genetical Structure of Populations, London, Chapman and Hall.
Mather, K, and Jinks, J L. 1982. Biometrical Genetics, 3rd ed., London, Chapman and Hall.
O'keefe, J, and Nadel, L. 1978. The Hippocampus as a Cognitive Map, Oxford, Clarendon Press.
Oliverio, A, Eleftheriou, B E, and Bailey, D W. 1973. Exploratory activity: Genetic analysis of its modification by scopolamine and amphetamine. Physiol Behav, 10, 893–899.
Roberts, R C. 1967. Some evolutionary implications of behavior. Can J Genet Cytol, 9, 419–435.
Simmel, E C, and Bagwell, M. 1983. Genetics of exploratory behavior and activity. In J. L. Fuller and E. C. Simmel (eds.), Behavior Genetics: Principles and Applications, London, Lawrence Erlbaum Assoc. Ltd.
Staats, J. 1976. Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res, 36, 4333–4377.
Staats, J. 1980. Standardized nomenclature for inbred strains of mice: Seventh listing. Cancer Res, 40, 2083–2128.
Van Abeelen, J H F. 1963. Mouse mutants studied by means of ethological methods. I. Ethogram. Genetica, 34, 79–94.
Van Abeelen. 1974. Genotype and the cholinergic control of exploratory behaviour in mice. In J. H. F. van Abeelen (ed.), The Genetics of Behaviour, Amsterdam, North-Holland and New York, American Elsevier.
Van Abeelen, J H F. 1975. Genetic analysis of behavioural responses to novelty in mice. Nature, 254, 239–241.
Van Abeelen, J H F. 1977. Rearing responses and locomotor activity in mice: Single-locus control. Behav Biol, 19, 401–404.
Van Der Laarse, W J, Crusio, W E, Maslam, S, and Van Abeelen, J H F. 1984. Genetic architecture of numbers of fast and slow muscle fibres in the mouse soleus muscle. Heredity, 53, 643–647.
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Crusio, W., van Abeelen, J. The genetic architecture of behavioural responses to novelty in mice. Heredity 56, 55–63 (1986). https://doi.org/10.1038/hdy.1986.8
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DOI: https://doi.org/10.1038/hdy.1986.8
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