Abstract
Restricted Maximum Likelihood (REML) with an animal model was used to estimate genetic parameters of body weight, body consumption and litter size of lines of mice selected for 20 generations on an index of lean mass at 10 weeks in males, highly correlated with body weight, and for a further 18 generations on body weight at 10 weeks in males and females. Univariate and multivariate estimates of heritability were about 0.5 and those of common environment correlations were about 0.25 for both body weight and composition. Body weight and fat pad weight had genetic and phenotypic correlations of about 0.5. The heritability estimate of litter size was about 0.15 from univariate analysis, rather lower from multivariate, and the estimate of its genetic correlation with body weight was about 0.25. There were reductions in heritability of both body weight and litter size in later generations, even though full pedigrees were fitted and inferences made to the base population, but a plateau in response to selection for increased body weight could not be explained by a complete attenuation of genetic variance.
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Beniwal, B K, Hastings, I M, Thompson, R, and Hill, W G. 1992. Estimation of changes in genetic parameters in selected lines of mice using REML with an animal model. 1. Lean mass. Heredity, 69, 352–360.
Brien, F D, Sharp, G L, Hill, W G, and Robertson, A. 1984. Effects of selection on growth, body composition and food intake and mice. II. Correlated responses in reproduction. Genet Res, 44, 73–85.
Eisen, E J. 1989. Selection experiments for body composition in mice and rats: A review. Livest Prod Sci, 23, 17–32.
Hastings, I M, and Hill, W G. 1989. A note on the effect of different selection criteria on carcass composition in mice. Anim Prod, 48, 229–233.
Hastings, I M, Yang, J, and Hill, W G. 1991. Analysis of lines of mice selected on fat content. 4. Correlated responses in growth and reproduction. Genet Res 58, 253–259.
McCarthy, J C. 1982. The laboratory mouse as a model for animal breeding. A review of selection for increased body weight and litter size. Proc 2nd World Congr Genet Appl Livest Prod, Madrid, 5, 66–83.
McCarthy, J C, and Doolittle, D P. 1977. Effect of selection for independent changes in two highly correlated body weight traits of mice. Genet Res, 29, 133–145.
Meyer, K. 1988. DFREML-Programs to estimate variance components for individual animal models by Restricted Maximum Likelihood (REML). User Notes. Institute of Animal Genetics, University of Edinburgh, Edinburgh, U.K.
Meyer, K, and Thompson, R. 1984. Bias in variance and covariance component estimators due to selection on a correlated trait. Z Tierz Zuchtbiol 101, 33–50.
Roberts, R C. 1960. The effects on litter size of crossing lines of mice inbred without selection. Genet Res, 1, 239–252.
Sharp, G L, Hill, W G, and Robertson, A. 1984. Effects of selection on growth, body composition and food intake in mice. I. Responses in selected traits. Genet Res, 43, 75–92.
Thompson, R, and Hill, W G. 1990. Univariate REML analyses for multivariate data with the animal model. Proc 4th World Congr Genet Appl Livest Prod, Edinburgh, 12, 484–487.
Visscher, P, and Thompson, R. 1990. REML estimates of parameters for fat yield in pedigree herds in the U.K. using an individual animal model: Male and female heritability esimates. Proc 4th World Congr Genet Appl Livest Prod, Edinburgh, 14, 484–487.
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Beniwal, B., Hastings, I., Thompson, R. et al. Estimation of changes in genetic parameters in selected lines of mice using REML with an animal model. 2. Body weight, body composition and litter size. Heredity 69, 361–371 (1992). https://doi.org/10.1038/hdy.1992.136
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DOI: https://doi.org/10.1038/hdy.1992.136
