Figure 2
From: Controlling false positives in the mapping of epistatic QTL
The FPR profiles of mapping epistatic pairs generated from different search paths in different non-epistatic genetic backgrounds and their controls. Along the x axis are six non-epistatic scenarios (from the left) simulating a genetic background with neither polygenic nor marginal-effect QTL effects, polygenic plus either zero, one, two, five or eight marginal-effect QTL effects. Within each non-epistatic scenario, any epistatic QTL pair detected from either the 2D_path (a full two-dimensional genome scan irrespective of pre-identified QTL, using 5% genome-wide thresholds) or the 1D_path (one-dimensional genome scans for each pre-identified QTL, using 5% genome-wide thresholds) counted as false positives. The 1D_path_corrected FPR calculated by testing each false positive pair from the 1D_path against stringent thresholds corrected by the number of pre-identified QTL. The Final FPR calculated by combing the FPR results from the 2D_path and the 1D_path_corrected after skipping any overlaps.
