Figure 3 | Heredity

Figure 3

From: Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations

Figure 3

Amino acid alignment of H-2Aa and H-2Eb exon 2. Alignment of loci and codon numbering follows the IMGT (international ImMunoGeneTics information system) (Lefranc et al., 2005), based on structural and functional comparisons. Codons present at one locus but absent in the other are in grey. Parts of H-2Aa sequence that were not genotyped are dotted. Sequences are aligned against GenBank reference sequences for mouse MHC. The alleles that have been sequenced previously have the GenBank accession numbers attached. Antigen-binding codons (ABS) and codons under selection are shown below the alignments. Selection was analysed for three groups of sequences: musculus, domesticus and pooled musculus, domesticus and hybrid-specific sequences (m+d+H). Positively selected codons identified by random effects likelihood (REL), fixed effects likelihood (FEL) and single likelihood ancestral counting (SLAC) are shown as black squares, by OmegaMap as grey squares, negatively selected codons as shaded squares and antigen-binding codons as asterisks.

Back to article page