Table 2 Amino-acid positions inferred to be positively selected under model M8 as implemented in PAML

Region	Amino-acid range	Positively selected amino-acid positions
	1–12	5^, 6^, 8^*
Hypervariable region a	13–32	18^*, 19^, 20^, 22^, 25^, 30^, 32^*
	33–43	None
Hypervariable region b	44–54	47^, 50^
	55–61	57 ^**
Conserved region 3	62–67	None
	68–82	68 ^*
Conserved region 4	83–90	None
	91–141	138^*

Positions in bold identify those sites in which the amino-acid position was also inferred as positively selected in two independent studies (Igic et al., 2007; Vieira et al., 2007); underlined positions indicate convergence with at least one of these studies. Alignment available on request.
^*P⩾0.95, ^**P⩾0.99.

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