Table 1 A representative list of well-studied specific DNA-binding transcription factors that regulate mouse lens and/or retinal development and their interactions with chromatin remodeling enzymes
From: Epigenetic regulatory mechanisms in vertebrate eye development and disease
Name | Class | Process | Molecular mechanismsa (activator—A, repressor—R) |
|---|---|---|---|
Rax | HD | RPC, MGC/spec | A/R |
Pax6 | HD, PD | RPC/prolif, LPC/spec/prolif/diff, LFC/diff, RGC/spec, AM/spec/diff, HR/spec/diff | A/R, binds EP300, Brg1 and TBP |
Six3 | HD | RPC, LPC/spec/prolif | A/R, binds Groucho co-repressors |
Six5 | HD | LFC/diff | A/R, binds Eya tyrosine phosphatases |
Six6 (Optx2) | HD | AM/spec/diff, HR/spec/diff | Â |
Lhx2 | HD | RPC | A/R |
Dlx1 | HD | RGC/diff | Â |
Dlx2 | HD | RGC/diff, LFC/diff | Binds GRIP1 co-activator |
Dlx5 | HD | RGC/diff, LFC/diff | Binds GRIP1 co-activator |
Pitx3 | HD | LFC/diff | A/R, binds co-repressor PSF |
Prox1 | HD | LFC/diff, AM/spec | A/R, binds p300/CBP, sumoylation modulates interactions with HDAC3 |
Otx2 | HD | RPE/spec/diff, BPC/spec/diff, ROD/spec/diff | Â |
Crx | HD | PH/spec, CONE/spec/diff | A/R, binds p300/CBP, regulated by sumoylation |
Vsx1 | HD | BP/diff | Â |
Vsx2 (Chx10) | HD | BP/spec | Â |
Isl1 | HD | AM/diff, BP/diff | A, binds estrogen receptor (ER) |
Lim1 | HD | HR/spec | Â |
Vax1 | HD | optic stalk/spec | Â |
Meis1 | HD | RPC/prolif, LPC/prolif, LFC/diff | A |
Meis2 | HD | RPC/prolif | A |
Vax2 | HD | optic stalk/spec | R, subcellular localization regulated by phosphorylation |
Zeb1 (Sip1) | HD-ZnF | LFC/diff, RPE/diff | Binds p300/CBP |
Pou2f1 (Oct-1) | POU HD | LPC/prolif | A/R, binds TBP and Groucho co-repressors |
Pou4f1 (Brn3a) | POU HD | RGC/spec/diff | Â |
Pou4f2 (Brn3b) | POU HD | RGC/spec/diff | Â |
Atoh7 (Math5) | bHLH | RGC/spec/diff | Â |
BHLHE22 | bHLH | AC/spec, BP/spec | Â |
Hes1 | bHLH | RPC/spec/prolif, MGC/spec/diff | A/R |
Hes5 | bHLH | MGC/spec/diff | Â |
Hes6 | bHLH | RPC/spec/diff | A |
Hesr2 | bHLH | MGC/spec | Â |
Mash1 | bHLH | ROD/spec, BP/spec | A, binds p300/CBP |
NeuroD1 | bHLH | NPC/spec/diff, ROD/spec/diff, AM/spec/diff, | A, binds p300/CBP |
Neurod4 (Math3) | bHLH | RPC/spec/diff | Â |
Mitf | bHLH-LZ | RPE/diff | Binds p300/CBP HATs and Brg1 (SWI/SNF) |
Ptf1a | bHLH | AC/diff, HC/diff | Â |
Sox11 | HMG | LPC/spec | Â |
Sox2 | HMG | LPC | A/R, binds p300/CBP and Sin3a/HDAC |
Sox1 | HMG | LFC/diff | Does not bind p300/CBP |
Sox9 | HMG | MGC/spec/diff | Binds p300/CBP |
Nr2e1 | NR-ZnF | ROD/spec/diff | Â |
Nr2e3 | NR-ZnF | ROD/spec/diff | A/R, binds Ret-CoR with HDAC, regulated by sumoylation |
Nr2f1 (COUP-TFI) | NR-ZnF | Optic vesicle/spec/diff | Â |
Nr2f2 (COUP-TFII) | NR-ZnF | Optic vesicle/spec/diff | A/R, Binds p300/CBP and HDAC1 |
Trß2 | NR-ZnF | CONE/spec/diff | A/R, NCOA1/6, NCOR1/2, |
RXRγ | NR-ZnF | CONE/spec/diff | A/R, binds p300/CBP |
ATF4 (CREB2) | bZIP | LFC/diff | Binds p300/CBP and PCAF |
c-Maf | bZIP | LFC/diff | Binds p300/CBP |
Nrl | bZIP | ROD/spec/diff | A, binds TBP |
Foxe3 | FKH | LPC/spec | Â |
Foxn4 | FKH | HR/spec | Â |
Tbx2 | T-box | Optic cup (D/V axis spec) | Binds Brg1 |
Tbx5 | T-box | Optic cup (D/V axis spec) | Â |
AP-2α | AP2 | LPC/spec | Binds p300/CBP |
GATA-3 | ZnF | LFC/diff | Binds peroxisome proliferator activator receptor (PPAR)-binding protein (PBP) and p300/CBP |
Hsf4 | HTH | LFC/diff | A, binds Brg1 (SWI/SNF) |
Pax2 | PD | Optic stalk/nerve spec | Binds PTIP complex with MLL3 |
pRb | Not definedb | LFC/diff, RPC/diff, CONE/diff | Binds ARID4A, BRG1, DNMT1, HDAC1/2/3, KDM5A, KMT1A/SUV39H1, p300/CBP |
