Table 2 Representative common nuclear targets of major signal transduction pathways
From: Epigenetic regulatory mechanisms in vertebrate eye development and disease
Signaling | TF | DNA-binding domain/consensus site (5′–3′) | Molecular mechanisms |
|---|---|---|---|
Receptor tyrosine kinase (FGF-MAPK and Ras) | AP-1 | bZIP TGA(G/C)T(C/A)A | A/R; bind p300/CBP HATs |
Ets | ETS GGA(A/T) | For example, ETS-1, ETS-2, Elf1, and ER81 (bind p300/CBP HATs) | |
TGF-β/BMP | Smad2 | MH1 GATC | Binds p300 and PCAF HATs and BRG1 |
Smad4 | MH1 GATC | Binds p300/CBP HATs, forms complex with Smad2/3 | |
Hedgehog | Gli2 | ZnF GACCACCCA | |
Gli3 | ZnF GACCACCCA | Binds p300/CBP HATs | |
Notch | RBPJ/CBF1/Su(H) | RHR GTG(A/R)GA(A/G) | A/R; binds PCAF and p300 HATs, and CtBP and NCOR2 co-repressors, makes complex with NICD of Notch |
Wnt | LEF/TCF | HMG CTTTG(A/T)(A/T) | Binds β-catenin and p300 HAT |
β-catenin | None | Binds LEF/TCF and p300/CBP HATs | |
CREB | bZIP TGACGT(A/C)(A/G) | Binds p300/CBP HATs | |
Nuclear receptorsa | RARα/β/γ | ZnF (A/G)G(G/T)TCAN1−5 (A/G)G(G/T)TCA | A/R, bind p300/CBP HATs, NCOA2/3/6, NCOR1/2 |
RXRα/β/γ | ZnF | A/R, bind p300/CBP HATs, NCOA2/3/6 | |
TRβ2 | ZnF AGGTCA | ||
RORα/β | ZnFTAA(A/T)NTAAGGTCA | Binds p300/CBP HATs |
