Table 3 A summary of protein domains that recognize core histone modificationsa

From: Epigenetic regulatory mechanisms in vertebrate eye development and disease

Reader domain (module)

Examples of vertebrate proteins

Preferred histone mark(s) recognized

Royal domains

Chromodomain

CHD1, CHD3/4, Eaf3, RBP1,

H3 K9me2/3, H3 K21me2/3

Double chromodomain

HP1, CHD1

H3 K4me1/2/3

Tudor

KDM4A/B/C (JMJD2a/b/c), SETDB1, TDRD9,

H3 K4me3

Double/tandem tudor

Crb2, TP53BP1

H4 K20me2

MBT (malignant brain tumor)

L3MBTL1, SCML2, SFMBT

H3 K4me1, H4 K20me1/2

Others

  

Bromodomain

BRG1, CBP, EP300, BPTF

Many acetylated histones (Kac)

PHD finger

ATRX, BPTF, CBP, EP300,

H3 K4me3, H3 K4, H3 K9me3, H3 K36me3

WD40 repeat

WDR5

H3 R2/K4me2,

14-3-3

14-3-3ζ

H3 S10ph, H3 S28ph

BRCT (BRCA-1 C-terminal)

BRCA-1, TP53BP1

H2AX S139ph

  1. a For additional information, see Taverna et al. (2007).
Back to article page