Figure 5
From: Genomic imprinting mechanisms in embryonic and extraembryonic mouse tissues
In vitro models to study the imprinting mechanism. ES cells derived from the ICM can be differentiated in vitro providing a model of embryonic imprinted expression. Models of extraembryonic imprinted expression are TS cells derived from trophectoderm and XEN cells derived from primitive endoderm. Differentiation of ES cells into embryoid bodies (EBs) can form tissues expressing markers of visceral endoderm and resembling VYS, suggesting that this system may provide a model of extraembryonic imprinted expression.
