Table 6 The frequency of different genotypes in healthy (control) subjects (fc) and in malaria (diseased) patients (fd) and the OR for the four genotypes where the odds ratio is statistically significant (Modiano et al., 2001)

From: Population genetics of malaria resistance in humans

 

Genotype

 

AA

AC

AS

CC

SC

SS

f c

0.6641

0.2172

0.0954

0.0165

—

—

f d

0.8036

0.1641

0.0275

0.0012

  

OR

2.070

0.7075

0.2681

0.0715

—

—

Relative fitness

0.948

1.030

1.079

1.102

—

—

 

0.861

0.935

0.979

1

0.498

0.109

  1. Below are the estimated relative fitnesses for the four genotypes assuming the mortality from malaria is m=0.1. In the bottom row, these values are standardized by the fitness of genotype CC, the genotype with the highest fitness (Hedrick, 2004).
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