Table 8 The fitness values for β-globin genotypes are given on the left column when the normal genotype αα/αα is present at the α-globin locus and the fitness values for the α-globin genotypes are given across the top when the normal genotype AA is present at α-globin locus

From: Population genetics of malaria resistance in humans

β-globin genotype

α-globin genotype

 

αα/αα (1)

α/αα (1+ht)

−α/−α (1+t)

AA (1–s)

1–s

(1–s)(1+ht)

(1–s)(1+t)

AS (1)

1

1+ht

1+t

SS (0)

0

0

0

  1. The values in the table are the expected fitnesses, assuming no epistasis, for the two-locus genotypes obtained by multiplying the values on the left column by the values across the top.