Table 2 Genetic differentiation (FST) among major continental groups and HapMap 2 populations in comparison to other data sets

From: Worldwide genetic structure in 37 genes important in telomere biology

Gene sets or SNP data sets

Among HapMap 2 populations

Among regions

 

YRI vs CEU

YRI vs CHB+JPT

CEU vs CHB+JPT

 

Telomere biology genes (37 genes, 716 SNPs, N=1168)b

0.136

0.189

0.095

0.095a

 Shelterin genes

0.140

0.224

0.148

0.109

 Telomerase complex genes

0.130

0.161

0.071

0.072

 DNA repair genes

0.154

0.209

0.099

0.107

 Helicase genes

0.139

0.196

0.071

0.085

 Other telomere-associated genes

0.098

0.144

0.093

0.086

CVD genes (364 genes, 15 559 SNPs, N=270)c

0.139

0.158

0.095

—

 Blood circulation and gas exchange genes

0.129

0.158

0.062

—

 Lipoprotein metabolism genes

0.144

0.165

0.082

—

 Insulin/IGF-mitogen-activated protein kinase kinase/ MAP kinase cascade genes

0.194

0.174

0.138

—

Disease associated SNPs (25 SNPs, N=952)d

—

—

—

0.10a

Innate immune genes (174 genes, 1396 SNPs, N=917)

—

—

—

0.11

Genome-wide autosomal SNP averagee

—

—

—

0.10–0.15

  1. Abbreviations: CEU, Utah; CHB, Han; CVD, cardiovascular disease; IGF, insulin-like growth factor; JPT, Japanese; MAP, mitogen-activated protein kinase; N=number of individuals; SNP, single-nucleotide polymorphism; YRI, Yoruba.
  2. aAmong the seven geographic regions represented in the CEPH-HGDP panel.
  3. bSee methods for a description of genes included in each gene set.
  4. c(Kullo and Ding, 2007)
  5. d(Myles et al., 2008)
  6. e(Akey et al., 2002; Shriver et al., 2004, 2005; Weir et al., 2005).
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