Table 4 Proportion of marker pairs with significant linkage disequilibriuma using HapMap 2 and HGDP data

From: Worldwide genetic structure in 37 genes important in telomere biology

Telomere biology gene b

n

Population c

  

YRI (N=110)

CEU (N=90)

CHB (N=89)

Oceania (N=21)

America (N=41)

ATM

15

0.818

0.836

0.806

1.000

0.600

BLM

26

0.659

0.717

0.709

0.695

0.529

DDX1

16

0.733

0.697

0.581

0.308

0.552

MRE11A

16

0.783

0.825

1.000

0.982

0.582

NBN

24

0.593

0.575

0.721

0.577

0.559

NOLA3

13

0.745

0.615

0.641

0.462

0.731

PARP1

16

0.724

0.978

0.857

0.800

0.736

PARP2

10

0.714

0.600

0.750

0.619

0.667

PINX1

42

0.756

0.840

0.683

0.950

0.359

POT1

23

0.929

1.000

1.000

1.000

0.925

PRKDC

18

0.508

0.581

0.562

0.622

0.533

RAD50

19

0.634

0.756

0.864

0.652

0.527

RAD51AP1

12

0.848

0.911

0.889

0.933

0.622

RAD51L1

177

0.277

0.404

0.331

0.275

0.308

RAD51L3

11

0.444

0.929

0.489

0.286

0.571

RAD54L

10

0.714

0.917

0.750

NA

0.750

RECQL

33

0.679

0.750

0.939

0.570

0.772

RECQL5

7

0.714

1.000

1.000

0.533

0.762

RTEL1

10

0.528

0.778

0.821

0.528

0.578

TEP1

25

0.446

0.438

0.352

0.267

0.447

TERF1

18

0.713

0.895

0.758

0.706

0.721

TERF2

6

0.667

0.933

0.733

NA

NA

TERF2IP

8

0.667

0.429

0.571

0.467

NA

TERT

8

0.571

0.536

0.524

0.095

0.381

TNKS

52

0.813

0.797

0.879

0.703

0.606

TNKS2

11

0.855

0.867

0.822

0.639

0.556

WRN

43

0.680

0.769

0.710

0.492

0.690

  1. Abbreviations: CEU, Utah; CHB, Han; HGDP, Human Genome Diversity Panel; n, number of SNPs; N, number of individuals; NA, ⩽5 polymorphic pairs of loci; YRI, Yoruba.
  2. a See methods for a description of this analysis; significant LD refers to a significant P value for rejecting the null hypothesis of free recombination.
  3. b Only genes with >5 polymorphic pairs of loci are shown due to the uncertainty of the estimation with so few loci.
  4. c One population was chosen to represent Africa (YRI), Eurasia (CEU) and East Asia (CHB), due to limited sample sizes all of the populations in Oceania and America were combined.
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