Figure 1 | Heredity

Figure 1

From: CLIP Test: a new fast, simple and powerful method to distinguish between linked or pleiotropic quantitative trait loci in linkage disequilibria analysis

Figure 1

Change in the mean combination of apparent effects at the marker level for one trait as a function of the mean combination of apparent effects at the marker level for a second trait depending on the LD between the hypothetical QTLs for the two traits on chromosome 9 in position 700 000–800 000 of the human genome. The square of the mean combination of apparent effects at the marker level is expressed by the LD (r2) between the hypothetical QTLs and the remaining 105 markers. The two lefthand figures correspond to the hypothesis of close linkage, and the righthand figure corresponds to the hypothesis of pleiotropism. Under the pleiotropism assumption, points are on a straight line whereas they are not under the close linkage assumption. Dispersion around the straight line increases when the LD between QTLs decreases.

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