Figure 1

Alignment of FRE652 and RmInt1 sequences. The ribozyme domains DI to DIV are underlined. Exon-binding sequences (EBS1, EBS2 and EBS3) are boxed, and relevant nucleotides corresponding to the first G residue of the RmInt1 intron and the ATG start codon of the IEP absent from FRE652 sequences are also boxed. Residues differing between FRE652 and the consensus are highlighted. Genomic positions, as shown from left to right, are: S. me GR4 pRmeGR4b (bases 73 323–73 974), S. md WSM419 pSMED02 (bases 1 062 090–1 061 452), S. me SM11 pSymA (bases 95 351–96 001), S. me C017 pHRC017 (bases 63 063–63 713), S. me AK83 pSymA copy 1 (bases 1 249 601–1 248 958), S. me AK83 pSymA copy 2 (bases 330 796–331 448) and S. me BL225C (bases 821 534–821 391).