Figure 2
Summary of the steps involved in implementing GMDR method. A balanced case–control study with no covariate is assumed for illustrative purpose in which a case has a score of 0.5 while a control does a score of −0.5. In step 3, bars represent hypothetical distributions of cases (left, dark shading) and controls (right, light shading); the numbers not in parentheses above bars are the numbers of cases/controls and those in parentheses above bars are sums of the scores. In steps 4 and 6, the numbers in parentheses are the average scores. Assuming an average score of 0.0 as the threshold, ‘high-risk’ cells are indicated by dark shading, ‘low-risk’ cells by light shading and ‘empty’ cells by no shading. A full color version of this figure is available at the Heredity journal online.
