Figure 4

Manhattan plots of power for trigenic interactions. The dummy coordinates along the x axis index the 1920 interactions while the power associated with each interaction is displayed on the y axis. SAGE represents the unified analysis for three subsamples: FSCD, COGEND, and COGA, while the meta-analysis is implemented with the Fisher’s combining P-value method for individual analyses of the three subsamples. The reference line in red is the average of power over the 1920 trigenic scenarios. A full color version of this figure is available at the Heredity journal online.