Table 1 Five hypotheses associated with the rate of genomic evolution and their predictions for the rate of karyotypic diversification (rKD) of mammals

From: A comparative study on karyotypic diversification rate in mammals

Hypotheses

Prediction

References

Non-neutral Hypothesis: Multiple causes and mechanisms such as meiotic drive, genetic drift and natural selection affect rKD.

rKD does not evolve neutrally, and will exhibit a significant phylogenetic signal.

1, 2, 3, 4

Metabolic Rate Hypothesis: Metabolic rates, when controlled for body mass, affect genomic mutation rates.

Lineages with higher metabolic rate in relation to body mass will show higher rKD.

5, 6, 7

Longevity Hypothesis: The efficiency of DNA repair mechanisms increases with body mass and longevity.

Lineages with larger and long-lived organisms will have lower rKD.

8, 9, 10

Reproduction Rate Hypothesis: More offspring per unit of time allows a higher chance of accumulating errors during DNA replication.

Lineages with higher litter size per year and earlier sexual maturity will have higher rKD.

11, 12

Geographic Range Hypothesis: Taxa with wider geographic distributions will have higher probability of fixation of genetic changes in different parts of their range.

Lineages with larger geographic distribution will have higher rKD.

13, 14

  1. References: (1) Charlesworth et al. (2003); (2) Dover (2002); (3) Villena and Sapienza (2001); (4) Molina et al. (2014); (5) Martin and Palumbi (1993); (6) Allen et al. (2006); (7) Barja and Herrero (2000); (8) Seluanov et al. (2009); (9) Munshi-South and Wilkinson (2010); (10) Bromham (2011); (11) Laird et al. (1969); (12) Li et al. (1996); (13) White (1978a, 1978b); (14) Hendry (2004).
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