Figure 1 | Heredity

Figure 1

From: Positive selection in cathelicidin host defense peptides: adaptation to exogenous pathogens or endogenous receptors?

Figure 1

The target’s diversity of LL-37 and proposed driving forces. (a) Membrane disruption and DNA binding mediating bacterial killing by LL-37; (b) Immune regulatory function of LL-37 on host immune cells via interacting with membrane receptors P2X7 and FPR2 and the intracellular receptor (glyceraldehydes 3-phosphate dehydrogenase, GAPDH) and DNA; (c) External or internal driving force for positive selection of CAP18-MP in mammals. PDB entries of the structures: 2K6O (LL-37); 2LNL (human CXCR1, the template for modeling human FPR2 structure); 4DW0 (zebrafish P2X4, the template for modeling human P2X7 structure); 1ZNQ (human GAPDH).

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