Figure 5 | Heredity

Figure 5

From: Positive selection in cathelicidin host defense peptides: adaptation to exogenous pathogens or endogenous receptors?

Figure 5

Molecular design of chimeric and truncated CAP18-MP. (a) Sequence alignment of CAP18-MP and related peptides. Regions under positive selection are boxed and shown in different colors, blue for human LL-37, green for the whale T. truncatus LL-37 and red for rabbit CAP18-MP(FV). PSSs are shadowed in yellow. Two chimeric mutants possess a MHR of CAP18-MP(FV) but non-identical NDR and CDR, one from human and another from whale. The truncated peptide CAP18- MP(FV)(2-31) was designed to remove the NDR and CDR. Experimental molecular weights determined by MALDI-TOF and retention times at the C18 column of CAP18(FV) and its mutants are shown here; (b). Structural models illustrating the design strategy where substitution and deletion were involved. Color codes are the same to a. Arrows indicate residues under positive selection.

Back to article page