Table 3 Lethal concentrations (CL, μM) of CAP18(FV) and its mutants against Gram-negative bacteria

From: Positive selection in cathelicidin host defense peptides: adaptation to exogenous pathogens or endogenous receptors?

 

CAP18(FV)

CAP18(FV)(2-31)

CAP18(FV)-HsNC

CAP18(FV)-TtNC

AF CGMCC 1.1837

1.80

1.92

2.31

2.65

EC ATCC 25922

1.46

1.63

2.07

2.75

EC DH5α

1.60

1.46

2.21

2.51

EC JM109

1.52

1.50

2.11

3.00

EC TOP10

1.62

1.33

1.93

2.85

EC Am. J16c

1.67

1.01

1.84

2.89

EC Am. J23a

1.44

1.33

1.95

2.89

EC CIP. J14b

2.19

1.77

2.67

2.17

EC D. G2b

2.19

1.33

3.49

3.85

EC D. J45b

2.19

1.41

2.67

5.23

SMAR ATCC 14041

NA

NA

NA

NA

PA O1

1.40

2.10

1.95

3.00

PA 14

2.04

2.67

3.22

3.75

PA FRD1

3.03

3.33

2.96

4.46

PA 374

1.79

4.42

4.77

3.89

PA 11082603

2.19

2.66

2.89

5.77

PA 11082616

2.91

3.54

1.47

7.20

PA 11092304

3.13

3.54

2.67

5.23

PA 11092618

2.91

2.66

1.84

4.34

PA DH

2.19

1.77

2.89

4.34

PA QT1

2.91

2.66

2.89

4.34

PS

1.46

2.19

1.78

2.31

SE ATCC 14028

1.21

1.47

2.65

1.08

SM DZ. 3G

1.94

2.92

3.70

2.17

SM WFH. 9N

1.67

1.41

1.95

2.05

SM WFM. 5N

1.67

3.54

2.67

2.17

SM ZQ. 17N

1.67

3.54

1.95

2.89

SM ZQ. 18X

1.67

3.54

2.89

2.89

SM ZQ. 21X

1.94

2.36

2.89

2.89

SMAL CGMCC 1.1788

3.93

2.99

3.21

10.67

Xanthomonas oryzae pv. oryzae

5.67

4.86

2.98

10.19

  1. Abbreviations: AF, Alcaligenes faecalis; EC, Escherichia coli; PA, Pseudomonas aeruginosa; PS, Pseudomonas solanacearum; SE, Salmonella enterica; SM, Salmonella; SMAL, Stenotrophomonas maltophilia; SMAR, Serratia marcescens. NA means 'no activity', as identified by no inhibition zone observed at 0.8 nmol peptide each well.
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