Table 2 The effect of recessive deleterious allelic effects on the rate of adaptation of the epistatic gene combination

Ploidy	Rate of recombination
	0	0.05	0.1	0.15	0.2	0.25	0.3	0.4	0.5
Diploid	260	471	1275	1746	1962	2086	2166	2263	2320
Autotetraploid
With the potential for chromosomal gametic disequilibrium
No double reduction	410	1045	1306	1352	1371	1381	1388	1395	1400
Double reduction	410	1036	1303	1353	1374	1387	1395	1406	1414
Without the potential for chromosomal gametic disequilibrium
No double reduction	409	1052	1319	1366	1386	1396	1403	1411	1415
Double reduction	409	1054	1320	1367	1386	1397	1404	1412	1417

For each type of ploidy the number of generations to reach 90% of maximum possible fitness is presented as a function of recombination rate, where it is assumed that the recombination rate is the same between the centromere and locus A and between loci A and B. Parameters assume recessive deleterious effects and correspond to Supplementary Figure 1b. All other parameter values are the same as in Figure 2.

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