Table 4 The effect of weak selection combined with additive deleterious allelic effects on the rate of adaptation of the epistatic gene combination

Ploidy	Rate of recombination
	0	0.05	0.1	0.15	0.2	0.25	0.3	0.4	0.5
Concave down epistasis ( Figure 1a)
Diploid	1948	6961	7216	7299	7340	7365	7381	7401	7413
Autotetraploid
With the potential for chromosomal gametic disequilibrium
No double reduction	3002	5738	5769	5779	5784	5787	5789	5791	5793
Double reduction	3002	5736	5766	5776	5781	5784	5785	5788	5790
Without the potential for chromosomal gametic disequilibrium
No double reduction	3002	5743	5774	5784	5789	5792	5794	5796	5798
Double reduction	3002	5743	5774	5784	5789	5792	5794	5797	5799
Weakly concave down epistasis ( Figure 1b)
Diploid	2438	9020	9316	9414	9463	9492	9512	9536	9550
Autotetraploid
With the potential for chromosomal gametic disequilibrium
No double reduction	4612	8390	8418	8427	8432	8434	8436	8438	8440
Double reduction	4612	8374	8390	8389	8384	8379	8374	8365	8357
Without the potential for chromosomal gametic disequilibrium
No double reduction	4612	8394	8422	8432	8436	8439	8441	8443	8445
Double reduction	4612	8394	8423	8432	8437	8439	8441	8443	8445

Strengths of selection are the same as in Table 3, but deleterious effects are additive as in Supplementary Figure 1a. The rate of adaptation is measured as the number of generations to reach 90% of maximum possible fitness.

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