Figure 1

Pedigree, panoramic radiographs and ocular findings. (a) Family pedigree. Squares indicate males and circles indicate females. Black and white symbols indicate affected and unaffected individuals, respectively. The arrow indicates the proband. Asterisks indicate individuals analyzed by whole-exome sequencing. Mut, mutation; wt, wild type. (b) Panoramic radiographs of the proband (III-3). Asterisks indicate tooth agenesis. (c) Ocular findings of proband’s mother (II-3). Arrowheads indicate iris hypoplasia.