Figure 2 | Human Genome Variation

Figure 2

From: Factor VII deficiency: a novel missense variant and genotype–phenotype correlation in patients from Southern Italy

Figure 2

(a) Multiple alignment of F7 sequences including the c.-54G nucleotide. Arrow indicates the c.-54G position. (b) PROMO software predictions of pattern of potential binding sites for TFs in F7 promoter sequences, comparing −54G (left side) to −54A (right side) alleles. The presence of −54A allele abolishes a binding site for c-Jun TF (within square brackets) and induces a novel binding site for the repressor YY1 TF (within square brackets).

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