Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Advertisement

Hypertension Research
  • View all journals
  • Search
  • Log in
  • Content Explore content
  • About the journal
  • Publish with us
  • Sign up for alerts
  • RSS feed
  1. nature
  2. hypertension research
  3. editorial comment
  4. article
Inflammation and Salt Sensitivity in the Early State of Hypertension
Download PDF
Download PDF
  • Editorial Comment
  • Published: 01 February 2007

Inflammation and Salt Sensitivity in the Early State of Hypertension

  • Tomohiro Katsuya1,
  • Hiromi Rakugi1 &
  • Toshio Ogihara1 

Hypertension Research volume 30, pages 105–107 (2007)Cite this article

  • 794 Accesses

  • Metrics details

Article PDF

References

  1. Yasui N, Kajimoto K, Sumiya T, Okuda T, Iwai N : The monocyte chemotactic protein-1 gene may contribute to hypertension in Dahl salt-sensitive rats. Hypertens Res 2007; 30: 185–193.

    Article  CAS  PubMed  Google Scholar 

  2. Manning RD Jr, Meng S, Tian N : Renal and vascular oxidative stress and salt-sensitivity of arterial pressure. Acta Physiol Scand 2003; 179: 243–250.

    Article  CAS  PubMed  Google Scholar 

  3. Meng S, Cason GW, Gannon AW, Racusen LC, Manning RD Jr : Oxidative stress in Dahl salt-sensitive hypertension. Hypertension 2003; 41: 1346–1352.

    Article  CAS  PubMed  Google Scholar 

  4. Manning RD Jr, Tian N, Meng S : Oxidative stress and antioxidant treatment in hypertension and the associated renal damage. Am J Nephrol 2005; 25: 311–317.

    Article  CAS  PubMed  Google Scholar 

  5. Tian N, Thrasher KD, Gundy PD, Hughson MD, Manning RD Jr : Antioxidant treatment prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension. Hypertension 2005; 45: 934–939.

    Article  CAS  PubMed  Google Scholar 

  6. Tian N, Rose RA, Jordan S, Dwyer TM, Hughson MD, Manning RD Jr : N-Acetylcysteine improves renal dysfunction, ameliorates kidney damage and decreases blood pressure in salt-sensitive hypertension. J Hypertens 2006; 24: 2263–2270.

    Article  CAS  PubMed  Google Scholar 

  7. Kobori H, Nishiyama A, Abe Y, Navar LG : Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet. Hypertension 2003; 41: 592–597.

    Article  CAS  PubMed  Google Scholar 

  8. Zhou MS, Hernandez Schulman I, Pagano PJ, Jaimes EA, Raij L : Reduced NAD(P)H oxidase in low renin hypertension: link among angiotensin II, atherogenesis, and blood pressure. Hypertension 2006; 47: 81–86.

    Article  CAS  PubMed  Google Scholar 

  9. Kobori H, Ozawa Y, Suzaki Y, et al: Young Scholars Award Lecture: intratubular angiotensinogen in hypertension and kidney diseases. Am J Hypertens 2006; 19: 541–550.

    Article  CAS  PubMed  Google Scholar 

  10. Katsuya T, Ishikawa K, Sugimoto K, Rakugi H, Ogihara T : Salt sensitivity of Japanese from the viewpoint of gene polymorphism. Hypertens Res 2003; 26: 521–525.

    Article  PubMed  Google Scholar 

  11. Szalai C, Duba J, Prohaszka Z, et al: Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 −2518 G/G genotype in CAD patients. Atherosclerosis 2001; 158: 233–239.

    Article  CAS  PubMed  Google Scholar 

  12. Larrousse M, Bragulat E, Segarra M, Sierra C, Coca A, de La Sierra A : Increased levels of atherosclerosis markers in salt-sensitive hypertension. Am J Hypertens 2006; 19: 87–93.

    Article  CAS  PubMed  Google Scholar 

  13. Chen XL, Tummala PE, Olbrych MT, Alexander RW, Medford RM : Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells. Circ Res 1998; 83: 952–959.

    Article  CAS  PubMed  Google Scholar 

  14. Tian N, Gu JW, Braddy SJ, Rose RA, Hughson MD, Manning RD Jr : Immune suppression prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension. Am J Physiol Heart Circ Physiol 2006 ( PMID 17040973).

  15. Nakagawa T, Kang DH, Ohashi R, et al: Tubulointerstitial disease: role of ischemia and microvascular disease. Curr Opin Nephrol Hypertens 2003; 12: 233–241.

    Article  CAS  PubMed  Google Scholar 

  16. Julius S, Nesbitt SD, Egan BM, et al: Feasibility of treating prehypertension with an angiotensin-receptor blocker. N Engl J Med 2006; 354: 1685–1697.

    Article  CAS  PubMed  Google Scholar 

  17. Aljada A, Ghanim H, Saadeh R, Dandona P : Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells. J Clin Endocrinol Metab 2001; 86: 450–453.

    CAS  PubMed  Google Scholar 

  18. Lalioti MD, Zhang J, Volkman HM, et al: Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet 2006; 38: 1124–1132.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan

    Tomohiro Katsuya, Hiromi Rakugi & Toshio Ogihara

Authors
  1. Tomohiro Katsuya
    View author publications

    Search author on:PubMed Google Scholar

  2. Hiromi Rakugi
    View author publications

    Search author on:PubMed Google Scholar

  3. Toshio Ogihara
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Tomohiro Katsuya.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Katsuya, T., Rakugi, H. & Ogihara, T. Inflammation and Salt Sensitivity in the Early State of Hypertension. Hypertens Res 30, 105–107 (2007). https://doi.org/10.1291/hypres.30.105

Download citation

  • Received: 18 December 2006

  • Issue date: 01 February 2007

  • DOI: https://doi.org/10.1291/hypres.30.105

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

Keywords

  • prehypertension
  • metabolic syndrome
  • renin-angiotensin aldosterone system
  • monocyte chemotactic protein-1

This article is cited by

  • The therapeutic potential of BRD4 in cardiovascular disease

    • Shigang Lin
    • Lizhong Du

    Hypertension Research (2020)

Download PDF

Advertisement

Explore content

  • Research articles
  • Reviews & Analysis
  • News & Comment
  • Current issue
  • Collections
  • Sign up for alerts
  • RSS feed

About the journal

  • Journal Information
  • Open Access Fees and Funding
  • Guide to Authors
  • About the Editors
  • Message from Editors
  • Call for Paper
  • Contact
  • About the Partner
  • For Advertisers
  • Subscribe
  • Showcase of Graphical Abstracts on Hypertension Research

Publish with us

  • For Authors & Referees
  • Language editing services
  • Open access funding
  • Submit manuscript

Search

Advanced search

Quick links

  • Explore articles by subject
  • Find a job
  • Guide to authors
  • Editorial policies

Hypertension Research (Hypertens Res)

ISSN 1348-4214 (online)

ISSN 0916-9636 (print)

nature.com sitemap

About Nature Portfolio

  • About us
  • Press releases
  • Press office
  • Contact us

Discover content

  • Journals A-Z
  • Articles by subject
  • protocols.io
  • Nature Index

Publishing policies

  • Nature portfolio policies
  • Open access

Author & Researcher services

  • Reprints & permissions
  • Research data
  • Language editing
  • Scientific editing
  • Nature Masterclasses
  • Research Solutions

Libraries & institutions

  • Librarian service & tools
  • Librarian portal
  • Open research
  • Recommend to library

Advertising & partnerships

  • Advertising
  • Partnerships & Services
  • Media kits
  • Branded content

Professional development

  • Nature Awards
  • Nature Careers
  • Nature Conferences

Regional websites

  • Nature Africa
  • Nature China
  • Nature India
  • Nature Japan
  • Nature Middle East
  • Privacy Policy
  • Use of cookies
  • Legal notice
  • Accessibility statement
  • Terms & Conditions
  • Your US state privacy rights
Springer Nature

© 2025 Springer Nature Limited