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Reproducibility of Nocturnal Blood Pressure Assessed by Self-Measurement of Blood Pressure at Home
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  • Original Article
  • Published: 01 August 2007

Reproducibility of Nocturnal Blood Pressure Assessed by Self-Measurement of Blood Pressure at Home

  • Keiko Hosohata1,
  • Masahiro Kikuya2,
  • Takayoshi Ohkubo1,3,
  • Hirohito Metoki3,4,
  • Kei Asayama1,3,
  • Ryusuke Inoue3,
  • Taku Obara2,
  • Junichiro Hashimoto1,3,
  • Kazuhito Totsune2,3,
  • Haruhisa Hoshi5,
  • Hiroshi Satoh6 &
  • …
  • Yutaka Imai2,3 

Hypertension Research volume 30, pages 707–712 (2007)Cite this article

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Abstract

To assess the reproducibility of nocturnal blood pressure (BP) during sleep as measured using a self-measurement device at home, we obtained repeated nocturnal home BP at 0200 h and quality of sleep assessment from a diary in 556 subjects (71% women, 62.4±11.1 years) in the general population. We used an Omron device (HEM-747IC-N, Omron Healthcare Co., Ltd., Kyoto, Japan), with which the time and frequency of monitoring can be preset and the readings stored. The mean±SD of the difference between test-retest BP measurements was 0.7±15.1 mmHg systolic and 0.2±9.7 mmHg diastolic with a mean interval of 5.9 days. The absolute differences were greater than 10 mmHg in 261 (46.9%) subjects for systolic and 145 (26.0%) subjects for diastolic. There was no evidence of regression to the mean in nocturnal measurements over at least three nights (n=390, p>0.22). The differences (the first minus the second measurement) were large in subjects who experienced sleep disturbance only in the first (n=64, 2.3±13.6 mmHg and 1.6±9.6 mmHg for systolic and diastolic, respectively) or second sessions (n=56, −4.1±16.4 mmHg and −2.5±11.4 mmHg) compared with the subjects without sleep disturbance (n=66, 1.5±17.8 mmHg and 0.8±10.3 mmHg) and those with sleep disturbance (n=370, 0.9±14.5 mmHg and 0.2±9.3 mmHg) in both sessions. In conclusion, the reproducibility of single nocturnal BP as assessed using a self-measurement device at home was not good, especially for subjects who experienced different quality of sleep in each session. To evaluate nocturnal BP using a self-measurement device, estimation of quality of sleep is indispensable.

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Author information

Authors and Affiliations

  1. Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan

    Keiko Hosohata, Takayoshi Ohkubo, Kei Asayama & Junichiro Hashimoto

  2. Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan

    Masahiro Kikuya, Taku Obara, Kazuhito Totsune & Yutaka Imai

  3. Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Tohoku University 21st Century COE Program, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan

    Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Junichiro Hashimoto, Kazuhito Totsune & Yutaka Imai

  4. Department of Medical Genetics, Tohoku University Graduate School of Medicine, Sendai, Japan

    Hirohito Metoki

  5. Ohasama Hospital, Iwate, Japan

    Haruhisa Hoshi

  6. Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan

    Hiroshi Satoh

Authors
  1. Keiko Hosohata
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  2. Masahiro Kikuya
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Corresponding author

Correspondence to Masahiro Kikuya.

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Cite this article

Hosohata, K., Kikuya, M., Ohkubo, T. et al. Reproducibility of Nocturnal Blood Pressure Assessed by Self-Measurement of Blood Pressure at Home. Hypertens Res 30, 707–712 (2007). https://doi.org/10.1291/hypres.30.707

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  • Received: 30 October 2006

  • Accepted: 15 March 2007

  • Issue date: 01 August 2007

  • DOI: https://doi.org/10.1291/hypres.30.707

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Keywords

  • self measurement
  • reproducibility
  • general population
  • nocturnal blood pressure
  • Omron HEM-747IC-N

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