Figure 1 | Hypertension Research

Figure 1

From: Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells: a role of acidosis-induced c-Src activation

Figure 1

Effects of human coupling factor 6 (CF6) on the gene expression of sFlt-1 and vascular endothelial growth factor receptor-2 (VEGFR-2) in human umbilical vein endothelial cells. (a) Chronological changes after exposure to CF6 at 10−7 M (n=6). *P<0.05. (b) Dose-related changes after 24-h exposure to CF6 at 10−9–10−6 M (n=3–7). *P<0.05. (c) Effects of CF6 on the ratios of sFlt-1 to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA at 24 h and effects of various compounds on CF6-induced increase in sFlt-1 gene expression (n=4–6). *P<0.05. Control (without agonists), CF6 at 10−7 M, PP1 at 50 μM, EF: efrapeptin at 10−5 M. (d) Effect of CF6 on the ratios of VEGFR-2, vascular endothelial growth factor (VEGF)-A, intercellular adhesion molecule-1 (ICAM-1) and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) to GAPDH mRNA at 24 h.

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