Table 5 Between- and within-family effect sizes associated with transmission of alleles

From: Left ventricular structure in relation to the human SAH gene in the European Project on Genes in Hypertension

Variable

N

Effect size±s.e.

  

Between-family

Within-family

  

Estimate

P-values

Estimate

P-values

Non-Slavic

 −1606A transmitted

LVMI (g m−2)

217

+2.89±2.57

0.26

−2.11±1.94

0.28

LVID (mm)

217

−1.93±0.68

0.005

−0.55±0.50

0.27

MWT (mm)

217

+0.15±0.18

0.42

−0.09±0.15

0.53

 −962del transmitted

LVMI (g m−2)

279

+1.62±1.67

0.33

+1.87±1.44

0.20

LVID (mm)

279

+0.12±0.45

0.79

−0.49±0.38

0.19

MWT (mm)

279

+0.12±0.12

0.33

+0.24±0.11

0.03

Slavic

 −1606A transmitted

LVMI (g m−2)

79

+0.48±3.04

0.88

+2.63±3.03

0.39

LVID (mm)

79

−0.03±0.67

0.96

+0.09±0.69

0.89

MWT (mm)

79

+0.08±0.20

0.69

+0.21±0.21

0.31

 −962del transmitted

LVMI (g m−2)

110

−1.77±2.14

0.41

−3.33±2.18

0.13

LVID (mm)

110

+0.40±0.48

0.41

+0.36±0.49

0.48

MWT (mm)

110

−0.27±0.14

0.055

−0.39±0.14

0.007

  1. N indicates the number of informative offspring. LVMI, LVID and MWT indicate left ventricular mass index, left ventricular end-diastolic internal diameter and mean wall thickness, respectively.
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