Figure 4 | Hypertension Research

Figure 4

From: Multivalent ligand–receptor interactions elicit inverse agonist activity of AT1 receptor blockers against stretch-induced AT1 receptor activation

Figure 4

The carboxyl group and the hydroxyl group as critical structures for olmesartan's inverse agonist activity against stretch-induced ERK activation. Rat neonatal cardiomyocytes (a) or HEK293-AT1 cells (b) were pretreated with indicated concentrations of olmesartan, R-239470 or R-90929, and stimulated by 10−7 M AngII (left) or by mechanical stretch (right). The activation of extracellular signal-regulated protein kinase (ERKs) was then determined. AT1, angiotensin II type 1.

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