Figure 5 | Hypertension Research

Figure 5

From: Multivalent ligand–receptor interactions elicit inverse agonist activity of AT1 receptor blockers against stretch-induced AT1 receptor activation

Figure 5

Comparison of the inverse agonist activities of olmesartan and losartan against stretch-induced ERK activation. HEK293-AT1 cells were stimulated by mechanical stretch, and the activation of extracellular signal-regulated protein kinase (ERKs) was determined. The inhibitory effect of 10−7 M olmesartan on stretch-induced ERK activation was much stronger than that of 10−7 M losartan. *P<0.01 vs. that of losartan. AT1, angiotensin II type 1.

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