Table 4 Relations of three polymorphisms to the prevalence of hypertension analyzed with a generalized estimating equation (first wave to fourth wave)
Gene symbol | Polymorphism | Subjects | Genotype | Hypertension | Control | P-value (dominant) | P-value (recessive) |
|---|---|---|---|---|---|---|---|
SORBS1 | 682A → G (Thr228Ala) | ||||||
Total | AA | 1792 (76.5) | 3818 (80.1) | 0.0039 | 0.1749 | ||
AG | 512 (21.9) | 896 (18.8) | |||||
GG | 39 (1.7) | 55 (1.2) | |||||
Women | AA | 847 (77.0) | 1891 (80.6) | 0.0249 | 0.3641 | ||
AG | 227 (20.6) | 417 (17.8) | |||||
GG | 26 (2.4) | 39 (1.7) | |||||
Men | AA | 945 (76.0) | 1927 (79.6) | 0.0628 | 0.2649 | ||
AG | 285 (22.9) | 479 (19.8) | |||||
GG | 13 (1.1) | 16 (0.7) | |||||
GCK | −30G → A | ||||||
Total | GG | 1639 (69.7) | 3006 (62.9) | 0.0068 | 0.5414 | ||
GA | 638 (27.1) | 1597 (33.4) | |||||
AA | 74 (3.1) | 175 (3.7) | |||||
Women | GG | 798 (72.3) | 1463 (62.1) | 0.0025 | 0.2016 | ||
GA | 279 (25.3) | 798 (33.9) | |||||
AA | 27 (2.5) | 95 (4.0) | |||||
Men | GG | 841 (67.4) | 1543 (63.7) | 0.3861 | 0.7655 | ||
GA | 359 (28.8) | 799 (33.0) | |||||
AA | 47 (3.8) | 80 (3.3) | |||||
WISP1 | 2364A → G | ||||||
Total | AA | 895 (38.2) | 1919 (40.2) | 0.0184 | 0.4578 | ||
AG | 1133 (48.3) | 2219 (46.5) | |||||
GG | 318 (13.6) | 635 (13.3) | |||||
Women | AA | 458 (41.7) | 929 (39.5) | 0.5437 | 0.2908 | ||
AG | 526 (47.9) | 1108 (47.1) | |||||
GG | 115 (10.5) | 315 (13.4) | |||||
Men | AA | 437 (35.0) | 990 (40.9) | 0.0074 | 0.0597 | ||
AG | 607 (48.7) | 1111 (45.9) | |||||
GG | 203 (16.3) | 320 (13.2) |
