Table 5 Relations of three polymorphisms to systolic and diastolic blood pressure (BP, mm Hg) in individuals not taking antihypertensive medication as analyzed with a mixed-effect model (first wave to fourth wave)

From: Association of polymorphisms of SORBS1, GCK and WISP1 with hypertension in community-dwelling Japanese individuals

Gene symbol

Polymorphism

  

Dominant model

P-value

Recessive model

P

SORBS1

682A → G (Thr228Ala)

  

AA

AG+GG

 

AA+AG

GG

 
  

Total

Sample no.

4407

1093

 

5432

68

 
   

Systolic BP

119.9±0.4

120.3±0.8

0.6179

119.9±0.4

123.7±3.1

0.2355

   

Diastolic BP

73.8±0.2

73.9±0.5

0.8963

73.8±0.2

76.6±1.9

0.1379

  

Women

Sample no.

2157

520

 

2627

50

 
   

Systolic BP

118.6±0.6

118.7±1.2

0.8973

118.5±0.5

124.7±3.7

0.0939

   

Diastolic BP

72.2±0.4

72.1±0.7

0.8528

72.1±0.3

76.4±2.2

0.0471

  

Men

Sample no.

2250

573

 

2805

18

 
   

Systolic BP

121.1±0.6

121.7±1.1

0.6246

121.3±0.5

117.1±6.2

0.5007

   

Diastolic BP

75.4±0.3

75.6±0.7

0.7841

75.5±0.3

73.3±3.7

0.5700

GCK

−30G → A

  

GG

GA+AA

 

GG+GA

AA

 
  

Total

Sample no.

3490

2020

 

5310

200

 
   

Systolic BP

120.3±0.5

119.4±0.6

0.2339

120.0±0.4

120.4±1.9

0.8164

   

Diastolic BP

74.1±0.3

73.4±0.4

0.1399

73.8±0.2

74.5±1.1

0.5721

  

Women

Sample no.

1683

1004

 

2580

107

 
   

Systolic BP

119.5±0.7

117.1±0.9

0.0262

118.6±0.5

118.9±2.7

0.9182

   

Diastolic BP

72.8±0.4

71.2±0.5

0.0120

72.2±0.3

72.7±1.6

0.7506

  

Men

Sample no.

1807

1016

 

2730

93

 
   

Systolic BP

121.0±0.6

121.7±0.8

0.5117

121.2±0.5

122.0±2.6

0.7819

   

Diastolic BP

75.3±0.4

75.7±0.5

0.6084

75.4±0.3

76.3±1.6

0.5897

WISP1

2364A → G

  

AA

AG+GG

 

AA+AG

GG

 
  

Total

Sample no.

2195

3309

 

4766

738

 
   

Systolic BP

119.1±0.6

120.5±0.5

0.0573

119.9±0.4

120.5±1.0

0.5698

   

Diastolic BP

73.3±0.3

74.2±0.3

0.0522

73.8±0.2

74.4±0.6

0.3371

  

Women

Sample no.

1074

1608

 

2330

352

 
   

Systolic BP

118.6±0.8

118.6±0.7

0.9498

118.6±0.6

118.9±1.5

0.8248

   

Diastolic BP

72.2±0.5

72.2±0.4

0.9953

72.2±0.3

72.4±0.9

0.8283

  

Men

Sample no.

1121

1701

 

2436

386

 
   

Systolic BP

119.6±0.8

122.3±0.6

0.0073

121.2±0.5

121.9±1.3

0.6141

   

Diastolic BP

74.4±0.5

76.1±0.4

0.0057

75.3±0.3

76.2±0.8

0.2939

  1. Systolic or diastolic BP was compared between two groups (dominant or recessive model) for each polymorphism, with adjustment for age and sex in all subjects or for age in women or men examined separately.
  2. P-values of <0.05 are shown in bold.
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