Table 2 Test of association between drinking behavior and 10 SNPs selected from four ethanol-metabolizing genes

From: Gene–environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population

    

Male

Female

dbSNP number

Gene symbol

Major (M)/ minor (m) allele

Orientation/ strand

Genotype

Allele

Genotype

Allele

    

χ2 test, P-value

MAF

χ2 test

OR (95%CI)

χ2 test, P-value

MAF

χ2 test

OR (95%CI)

    

Dominant/recessive/ 2 × 3 contingency

Nondrinker/ Drinker a

P-value

 

Dominant/Recessive/ 2 × 3 contigency

Nondrinker/ Drinker a

P-value

 

rs2276332

ADH1A

T/G

rev/B

0.007/0.565/0.026

0.05/0.01

0.008

1.51 (1.11–2.05)

0.032/0.161/0.064

0.06/0.02

0.019

1.51 (1.07–2.14)

rs1229984

ADH1B

A/G

fwd/T

0.047/0.013/0.020

0.21/0.25

0.010

1.26 (1.06–1.49)

2.4 × 10−5/4.6 × 10−5/1.8 × 10−6

0.22/0.06

5.5 × 10−7

1.68 (1.37–2.05)

rs4147536

ADH1B

G/T

fwd/B

0.698/0.754/0.910

0.08/0.02

0.664

1.06 (0.81–1.39)

0.317/0.266/0.400

0.08/0.02

0.235

1.21 (0.88–1.67)

rs11499823

ADH1C

T/C

fwd/B

0.579/0.590/0.711

0.04/0.01

0.639

1.09 (0.75–1.58)

0.047/0.534/0.101

0.05/0.01

0.062

1.44 (0.98–2.11)

rs4147541

ADH1C

G/C

fwd/B

0.855/0.236/0.492

0.14/0.03

0.608

1.06 (0.86–1.30)

0.046/0.047/0.040

0.14/0.03

0.020

2.94 (2.22–3.89)

rs1693431

ADH1C

A/C

rev/T

0.352/0.968/0.646

0.05/0.01

0.367

1.16 (0.81–1.62)

0.077/0.534/0.158

0.06/0.01

0.100

1.33 (0.94–1.88)

rs671

ALDH2

G/A

fwd/T

4.7 × 10−140/3.0 × 10−182/3.0 × 10−231

0.65/0.13

2.9 × 10−251

0.08 (0.07–0.09)

8.4 × 10−54/6.3 × 10−13/4.0 × 10−54

0.43/0.1

3.2 × 10−49

0.15 (0.12–0.20)

rs4646778

ALDH2

C/A

fwd/T

3.5 × 10−12/0.001/7.7 × 10−12

0.08/0.01

2.1 × 10−12

2.35 (1.84–3.00)

0.012/2.1 × 10−5/3.2 × 10−5

0.14/0.02

0.001

1.50 (1.18–1.91)

rs886205

ALDH2

G/A

rev/T

1.8 × 10−20/1.3 × 10−5/5.5 × 10−20

0.09/0.03

3.3 × 10−21

2.91 (2.31–3.67)

3.1 × 10−6/0.001/3.4 × 10−6

0.14/0.05

2.0 × 10−7

1.82 (1.45–2.29)

rs4646775

ALDH2

Del/Ins

fwd/B

1.2 × 10−39/7.4 × 10−18/5.5 × 10−43

0.18/0.02

3.0 × 10−43

3.34 (2.80–3.00)

1.0 × 10−7/1.4 × 10−10/2.7 × 10−12

0.29/0.07

2.9 × 10−12

1.94 (1.61–2.35)

  1. aDrinkers are defined as regular drinkers and past drinkers and chance drinkers are not included in the dichotomous analysis regarding drinking behavior.
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