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Effects of ‘pulse’ treatment with high-dose ARB or CCB from age 16 to 18 weeks on renal arteriolar hypertrophy in SHR. Abbreviations as in Figure 2. ++P<0.01 vs. untreated WKY; **P<0.01 vs. untreated SHR; ††P<0.01 vs. CCB-treated SHR (reproduced with permission from Ishiguro et al.25).
