Table 1 Summary of results of microanalysis of kidney mRNA expression at age 18 weeks in SHR treated with ARB or CCB
From: Prevention and regression of hypertension: role of renal microvascular protection
(a) Differences in mRNA expression of different gene groups in ARB-treated and CCB-treated rat kidneys | |||
|---|---|---|---|
Name of gene group | No. of genes | ||
Total genes | 28 000 | ||
Elevated in ARB-treated rats compared with CCB | |||
Total elevated | 1345 | ||
ECM-related genes | 12 | ||
Cell cycle-related genes | 35 | ||
Intracellular signal-related genes | 61 | ||
Oxidative stress-related genes | 8 | ||
Reduced in ARB-treated rats compared with CCB | |||
Total reduced | 5671 | ||
ECM-related genes | 71 | ||
Cell cycle-related genes | 119 | ||
Intracellular signal-related genes | 492 | ||
Oxidative stress-related genes | 26 | ||
(b) Differences in mRNA expression of ECM-related genes in ARB-treated and CCB-treated rat kidneys | |||
Name of ECM-related gene | Signal log ratio | Signal ratio | P-value |
Elevated in ARB-treated rats compared with CCB | |||
Procollagen type IV α-4 | 0.8 | 1.74 | 0.000035 |
MMP-15 | 0.6 | 1.52 | 0.001486 |
Reduced in ARB-treated rats compared to CCB | |||
Procollagen type XII α-1 | −0.7 | 0.616 | 0.999611 |
Laminin | −1.6 | 0.330 | 0.99997 |
Fibrillin | −0.7 | 0.616 | 0.998349 |
Elastin microfibril interfacer 2 | −0.7 | 0.616 | 0.999977 |
MMP-9 | −1.8 | 0.287 | 0.999508 |
TIMP-2 | −1.3 | 0.406 | 0.999853 |
TIMP-3 | −2.5 | 0.177 | 0.99998 |
