Figure 1 | Hypertension Research

Figure 1

From: A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects

Figure 1

(a) Molecular structures of irbesartan and losartan. (b) The effect of preincubation with either irbesartan or with losartan on Ang II-mediated inositol phosphate (IP) production in COS cells with transiently transfected wild-type (WT) and Y113A AT1 receptors. Cells were preincubated with or without the indicated concentrations of irbesartan or losartan for 30 min at 37 °C, and then further incubated for 5 min with increasing concentrations of Ang II. The percentage of maximal IP production in control cells without angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) (ARB(−)) with WT and Y113A AT1 receptors was adjusted to 100% (5934±411 c.p.m. and 3502±263 c.p.m., respectively).

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