Figure 2 | Hypertension Research

Figure 2

From: A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects

Figure 2

Percentage of the basal activity of inositol phosphate (IP) production with wild-type (WT) and Y113A AT1 receptors (a) or N111G and N111G/Y113A AT1 receptors (b) with the indicated concentrations of irbesartan and losartan. The percentage of basal activity without angiotensin II (Ang II) type 1 (AT1) receptor blocker (ARB) treatment in WT (971±84 c.p.m.), Y113A (947±57 c.p.m.), N111G (2240±98 c.p.m.) and N111G/Y113A (1650±82 c.p.m.) AT1 receptors were adjusted to 100%. Irbesartan and losartan were added 45 min before the measurement of IP. *P<0.05 vs. no treatment in each AT1 receptor. #P<0.05 vs. 1 μM losartan in each AT1 receptor.

Back to article page