Figure 3 | Hypertension Research

Figure 3

From: A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects

Figure 3

(a) Percentage of angiotensin II (Ang II) type 1 (AT1) receptor blocker (ARB) dissociation from the WT AT1 receptor after the first washing-out with the indicated concentrations of irbesartan and losartan. Closed and gray bars indicate losartan and irbesartan, respectively. *P<0.05 vs. losartan at the same concentration. (b) Percentage of ARB dissociation from the WT AT1 receptor by 1–3 washing-out procedures with 1 μM irbesartan and losartan. Closed and gray circles indicate losartan and irbesartan, respectively. *P<0.05 vs. losartan at the same washing-out procedure. (c) Percentage of ARB dissociation from the Y113A AT1 receptor by the first washing-out with 1 μM irbesartan and losartan. Closed and gray bars indicate losartan and irbesartan, respectively. NS, not significant.

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