Figure 6 | Hypertension Research

Figure 6

From: A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects

Figure 6

(a) Adiponectin accumulation in medium from 3T3L1 adipocytes after 2, 4, 6, 8 and 11 days of differentiation without (dotted line) and with 1 μM irbesartan (gray line) or 1 μM losartan (black line). *P<0.05 vs. no treatment and losartan at each time point. (b) Adiponectin accumulation in medium from 3T3L1 adipocytes after 11 days of differentiation without (open bar) and with 0.01, 0.1 and 1 μM irbesartan (gray bars) or 1 μM losartan (closed bar). *P<0.05 vs. no treatment and 1 μM losartan. (c) A receptor cofactor assay for peroxisome proliferator-activated receptor (PPAR)-γ using the indicated concentrations of angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) (without (open bar) and with 0.01, 0.1 and 1 μM irbesartan (gray bars) or 1 μM losartan (closed bar)). *P<0.05 vs. no treatment and 1 μM losartan. (d) PPAR-γ DNA-binding activities in nuclear extracts from 3T3L1 adipocytes after 11 days of differentiation without (open bar) and with 1 μM irbesartan (gray bar) or 1 μM losartan (closed bar). *P<0.05 vs. no treatment.

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