Figure 2
From: From aldosteronism to oxidative stress: the role of excessive intracellular calcium accumulation
A high-salt diet (for example, 8% NaCl) is accompanied by the suppression of plasma renin activity (PRA) and circulating levels of angiotensin (Ang) II and plasma aldosterone concentration (PAC). However, the accompanying hypercalciuria leads to plasma-ionized hypocalcemia, which, in turn, promotes secondary hyperparathyroidism with elevated plasma parathyroid hormone (PTH), and ultimately bone resorption. An activation of the hypothalamic-pituitary-adrenal (HPA) axis likewise accompanies hypocalcemia with ensuing elevations in plasma levels of adrenocorticotropin hormone (ACTH) and catecholamines. PTH, ACTH and catecholamines represent three different stimuli to the adrenal glands’ production of aldosterone. As a result, increased PAC can be found.
