Table 1 Clinical features, kidney function and MRI findings of the normal and cerebral atrophy groups
From: Marked cerebral atrophy is correlated with kidney dysfunction in nondisabled adults
Variables | Normal, n=585 (95.9%) | Cerebral atrophy, n=25 (4.1%) | P-value |
|---|---|---|---|
Clinical variables | |||
Age; median (IQR), years | 56.2 (49.3–63.0) | 70.5 (66.5–78.1) | <0.0001 |
Sex; male, n (%) | 281 (48.0) | 21 (84.0) | <0.0001 |
Hypertension, n (%) | 191 (32.6) | 14 (56.0) | 0.015 |
Diabetes mellitus, n (%) | 56 (9.6) | 1 (4.0) | 0.348 |
Hyperlipidemia, n (%) | 289 (49.4) | 12 (48.0) | 0.891 |
Smoking, n (%) | 109 (18.6) | 3 (12.0) | 0.402 |
Ischemic heart disease, n (%) | 17 (2.9) | 1 (4.0) | 0.752 |
Family history of stroke, n (%) | 171 (29.2) | 9 (36.0) | 0.467 |
SBP; median (IQR), mm Hg | 122 (110–134) | 130 (112–139) | 0.114 |
DBP; median (IQR), mm Hg | 76 (68–84) | 80 (74–82) | 0.187 |
Education; median (IQR), years | 12.0 (12.0–16.0) | 12.0 (9.0–12.5) | 0.203 |
MMSE score, median (IQR) | 30 (29–30) | 29 (27–30) | <0.0001 |
Kidney functions | |||
GFR; median (IQR), ml min−1 per 1.73 m2 | 77.3 (68.3–86.3) | 63.6 (54.6–75.5) | <0.0001 |
GFR <60, n (%) | 52 (8.9) | 10 (40.0) | <0.0001 |
MRI findings | |||
WMH, n (%) | |||
None | 283 (48.4) | 3 (12.0) | <0.0001 |
Punctate | 226 (38.6) | 6 (24.0) | |
Early confluent | 67 (11.5) | 10 (40.0) | |
Confluent | 9 (1.5) | 6 (24.0) | |
Presence of lacunes, n (%) | 22 (3.8) | 4 (16.0) | 0.003 |
