Table 2 Logistic regression analysis of factors relevant to cerebral atrophy

From: Marked cerebral atrophy is correlated with kidney dysfunction in nondisabled adults

 

Model 1

Model 2

Model 3

Model 4

Variables

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Age (per 10 years)

5.83 (2.86–11.89)

<0.0001

5.51 (2.66–11.39)

<0.0001

5.83 (2.82–12.04)

<0.0001

5.52 (2.64–11.54)

<0.0001

Male

4.85 (1.45–16.20)

0.010

4.87 (1.46–16.17)

0.010

5.19 (1.54–17.45)

0.008

5.31 (1.57–17.92)

0.007

Hypertension

0.69 (0.24–1.99)

0.495

0.74 (0.26–2.16)

0.583

0.63 (0.22–1.87)

0.407

0.67 (0.23–2.00)

0.477

WMH

1.98 (1.10–3.54)

0.022

2.02 (1.12–3.63)

0.020

2.34 (1.26–4.33)

0.007

2.39 (1.28–4.45)

0.006

Presence of lacunes

1.75 (0.31–9.92)

0.528

1.82 (0.31–10.74)

0.510

2.13 (0.39–11.66)

0.382

2.24 (0.39–12.81)

0.366

MMSE score

—

—

0.86 (0.64–1.16)

0.335

—

—

0.86 (0.63–1.16)

0.315

Kidney function

0.64 (0.42–0.98)

0.042

0.65 (0.42–1.00)

0.048

5.93 (1.82–19.27)

0.003

5.86 (1.80–19.16)

0.003

  1. Abbreviations: 95% CI, 95% confidence interval; GFR, glomerular filtration rate; MMSE, mini-mental state examination; OR, odds ratio; WMH, white matter hyperintensities.
  2. Variables were analyzed using the value of GFR (per 10 ml min−1 per 1.73 m2) in Models 1 and 2, and subject with GFR <60 ml min−1 per 1.73 m2 in Models 3 and 4.
  3. Analyses were performed without the MMSE score in Models 1 and 3, and with the MMSE score in Models 2 and 4.
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