Figure 1 | Hypertension Research

Figure 1

From: Connective tissue growth factor induction in a pressure-overloaded heart ameliorated by the angiotensin II type 1 receptor blocker olmesartan

Figure 1

Induction of CTGF and TGF-β mRNA and CTGF distribution in rat pressure-overloaded (PO) hearts. (a) Quantitative real-time RT-PCR analysis demonstrated that CTGF mRNA expression was significantly increased after 3 days of aortic banding (**P<0.01 vs. control group) (Cont., control group). (b) Quantitative real-time RT-PCR analysis of TGF-β1 mRNA expression showed that TGF-β mRNA was significantly increased after 7 days (*P<0.05 vs. control group). (c) Time course of CTGF distribution in the PO heart. CTGF-positive signals (brown) were observed in the perivascular fibrotic area at 3 days (arrows) and in both perivascular and intracellular fibrotic areas after 7 days of banding (arrows). Azan staining (blue) demonstrates a fibrotic area in the adjacent section after aortic banding (bottom). Scale bar: 100 μm.

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