Table 1 Hemodynamic measurements and organ weights

From: Connective tissue growth factor induction in a pressure-overloaded heart ameliorated by the angiotensin II type 1 receptor blocker olmesartan

 

Saline

Hydralazine

Olmesartan

7 day

 IVSd (mm)

1.62±0.15

1.45±0.10#

1.30±0.11##, *

 LVPW (mm)

1.68 ±0.13

1.57±0.10

1.35±0.08##, **

 SBP ( mm Hg)

142±11

109±10##

109±10##

 HW/BW ( × 10−3)

4.01±0.62

4.32±0.51

3.73±0.33*

28 day

 IVSd (mm)

1.57±0.08

1.70±0.14

1.22±0.08##, **

 LVPW (mm)

1.57±0.08

1.73±0.11#

1.28±0.08##, **

 SBP ( mm Hg)

135±5

114±5##

109±10##

 HW/BW ( × 10−3)

3.50±0.55

4.00±0.40

3.05±0.17*

Myocyte hypertrophy index

6.05±1.45

5.60±1.20

4.77±0.48##, *

  1. Abbreviations: BW, body weight; HW, heart weight; IVSd, end-diastolic interventricular septal thickness; LVPW, end-diastolic left ventricular posterior wall thickness; SBP, systolic blood pressure.
  2. #P<0.05 vs. saline; ##P<0.01 vs. saline; *P<0.05 vs. hydralazine; **P<0.01 vs. hydralazine.
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