Figure 2

Acetylcholine-induced vascular relaxation in noradrenaline-precontracted carotid arteries in WKY rats and placebo (P)-, candesartan (C)-, candesartan plus amlodipine (C+A)- and candesartan plus HCTZ (C+H)-treated SHR-SP (a). Gene expression of endothelial nitric oxide synthase (eNOS) in aortas obtained from the WKY rats and placebo (P)-, candesartan (C)-, candesartan plus amlodipine (C+A)- and candesartan plus HCTZ (C+H)-treated SHR-SP (b). *P<0.05 and **P<0.01 vs. placebo-treated SHR-SP. #P<0.05 vs. candesartan-treated SHR-SP.