Table 2 PRA, serum ACE activity and serum angiotensin II concentration

From: Candesartan and amlodipine combination therapy provides powerful vascular protection in stroke-prone spontaneously hypertensive rats

  

SHR-SP

Parameters

WKY rats (n=6)

Placebo (n=6)

Candesartan (n=6)

Candesartan+amlodipine (n=6)

Candesartan+HCTZ (n=6)

PRA (ng AI ml−1 per h)

6.0±0.6

5.9±1.0

15.9±1.5**

13.3±2.4**

17.1±0.8**

Serum ACE activity (mU ml−1)

95.0±4.9**

40.3±2.7

38.0±1.2

34.7±1.4

39.0±1.1

Serum angiotensin II Concentration (pg ml−1)

37.2±6.2

39.2±4.9

123±11**

108±25**

150±21**

  1. Abbreviations: ACE, angiotensin-converting enzyme; PRA, Plasma renin activity; HCTZ, hydrochlorothiazide; SHR-SP, stroke-prone spontaneously hypertensive rats; WKY, Wistar-Kyoto.
  2. Values are mean±s.e.m. **P<0.01 vs. placebo.
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