Table 1 Changes in each parameter are evaluated before and after administration of aliskiren (150 mg per day, every other day, for 2 months) in 31 hypertensive subjects with advanced diabetic nephropathy

From: Aliskiren reduces albuminuria and oxidative stress, and elevates glomerular filtration rates in Japanese patients with advanced diabetic nephropathy

 

Before

After

% Change

Urinary

 MCP-1 (pg mg−1 Cre)

503.3 (54.9–3144.0)

359.3 (38.8–2527.0)*

−24.1±5.0

 IL-6 (pg mg−1 Cre)

4.7 (0.2–36.5)

2.6 (0.2–18.5)*

−29.6±7.3

 8-OHdG (ng mg−1 Cre)

8.5 (4.3–17.5)

6.6 (4.4–14.8)*

−16.7±5.2

 ACR (μg mg−1 Cre)

1320.5 (429.8–3427.9)

841.6 (184.3–3783.1)*

−25.6±6.7

 SBP (mm Hg)

145.2±2.8

135.8±3.1*

−6.3±1.5

 eGFR (ml min−1)

45.3±2.2

51.1±2.5*

14.3±3.4

  1. Abbreviations: 8-OHdG, 8-hydroxydeoxyguanosine; ACR, urinary albumin to creatinine ratio; Cre, urinary creatinine excretion; eGFR, estimated glomerular filtration rate; IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein-1; SBP, systolic blood pressure.
  2. *P<0.05, geometric mean (range), mean±s.e.m.